BDBM678126 US20240174690, Example I-6

SMILES C[C@H](Oc1cc(nc(n1)-c1onc2c1CCC[C@@]21CCCc2sc(N)c(C#N)c12)N1C[C@H](C)N[C@@H](C)C1)[C@@H]1CCCN1C

InChI Key InChIKey=DNZUCCATXSQTCH-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 678126   

TargetGTPase KRas [G12D]/Son of sevenless homolog 1 [564-1049](Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM678126(US20240174690, Example I-6)
Affinity DataIC50: 1nMAssay Description:These assays measure the inhibitory effect of compounds on KRAS mutant protein-protein interactions using the Alpha Screen technology by Perkin Elmer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2024
Entry Details
Go to US Patent

TargetSon of sevenless homolog 1 [564-1049]/GTPase KRas [G12C](Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM678126(US20240174690, Example I-6)
Affinity DataIC50: 5nMAssay Description:These assays measure the inhibitory effect of compounds on KRAS mutant protein-protein interactions using the Alpha Screen technology by Perkin Elmer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2024
Entry Details
Go to US Patent