BDBM677844 US20240174674, Compound 3::US20240174674, Compound 59

SMILES CCOc1cc(-c2ccc(nc2)N2CCC(C)(CC2)NC(=O)c2ncccc2Cl)c2c3cn[nH]c3nn2c1

InChI Key InChIKey=AULIXHBNPUZLAF-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 677844   

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Applied Pharmaceutical Science

US Patent
LigandPNGBDBM677844(US20240174674, Compound 3 | US20240174674, Compoun...)
Affinity DataIC50: 0.100nMAssay Description:a) 10 nL of compound dilution was transferred to each well of the test plate;b) the compound plate was centrifuged at 1000 g for 1 min;c) the test pl...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret [V804M](Human)
Applied Pharmaceutical Science

US Patent
LigandPNGBDBM677844(US20240174674, Compound 3 | US20240174674, Compoun...)
Affinity DataIC50: 0.100nMAssay Description:a) 10 nL of compound dilution was transferred to each well of the test plate;b) the compound plate was centrifuged at 1000 g for 1 min;c) the test pl...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret [G810R](Human)
Applied Pharmaceutical Science

US Patent
LigandPNGBDBM677844(US20240174674, Compound 3 | US20240174674, Compoun...)
Affinity DataIC50: 2.90nMAssay Description:a) 10 nL of compound dilution was transferred to each well of the test plate;b) the compound plate was centrifuged at 1000 g for 1 min;c) the test pl...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret [G810R](Human)
Applied Pharmaceutical Science

US Patent
LigandPNGBDBM677844(US20240174674, Compound 3 | US20240174674, Compoun...)
Affinity DataIC50: 4.60nMAssay Description:a) 10 nL of compound dilution was transferred to each well of the test plate;b) the compound plate was centrifuged at 1000 g for 1 min;c) the test pl...More data for this Ligand-Target Pair
In DepthDetails
US Patent