BDBM677325 US20240174652, Example 1::US20240174652, Example 1-1

SMILES Cc1cnc(cn1)C(=O)N[C@@H]([C@H]1COCCO1)c1nc2cc(ccc2n1C)C(F)(F)F

InChI Key InChIKey=QXRPIJGSGYOWEE-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 677325   

TargetMetabotropic glutamate receptor 4(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM677325(US20240174652, Example 1 | US20240174652, Example ...)
Affinity DataIC50: 20nMAssay Description:The in vitro activity of the compounds according to the invention may be investigated as follows:[0111]The HEK293 cell overexpressing the human metab...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/18/2024
Entry Details
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TargetMetabotropic glutamate receptor 4(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM677325(US20240174652, Example 1 | US20240174652, Example ...)
Affinity DataIC50: 67nMAssay Description:The in vitro activity of the compounds according to the invention may be investigated as follows:[0111]The HEK293 cell overexpressing the human metab...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/18/2024
Entry Details
Go to US Patent

TargetMetabotropic glutamate receptor 4(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM677325(US20240174652, Example 1 | US20240174652, Example ...)
Affinity DataIC50: 20nMAssay Description:In Vitro Testing of mGluR4 Potency The in vitro activity of the compounds according to the invention may be investigated as follows: The HEK293 cell ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2024
Entry Details
Go to US Patent

TargetMetabotropic glutamate receptor 4(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM677325(US20240174652, Example 1 | US20240174652, Example ...)
Affinity DataIC50: 67nMAssay Description:In Vitro Testing of mGluR4 Potency The in vitro activity of the compounds according to the invention may be investigated as follows: The HEK293 cell ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2024
Entry Details
Go to US Patent