BDBM677025 US11993596, Compound WX055::US20240294526, Compound WX055

SMILES CCOc1cc2CCn3c(c\c(=N/c4c(C)cc(C)cc4C)n(CCC(=O)Nc4cnn[nH]4)c3=O)-c2cc1OC

InChI Key InChIKey=DLGRLMFWMXBMLC-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 677025   

TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A(Human)
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM677025(US11993596, Compound WX055 | US20240294526, Compou...)
Affinity DataIC50: 0.0400nMAssay Description:Procedure:1. The recombinant human PDE4B enzyme and enzyme substrate (1 uM cAMP) were each dissolved in newly prepared experimental buffer solution;2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
Go to US Patent

TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Human)
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM677025(US11993596, Compound WX055 | US20240294526, Compou...)
Affinity DataIC50: 2.10nMAssay Description:Procedure:1. The recombinant human PDE4B enzyme and enzyme substrate (1 uM cAMP) were each dissolved in newly prepared experimental buffer solution;2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
Go to US Patent

TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A(Human)
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM677025(US11993596, Compound WX055 | US20240294526, Compou...)
Affinity DataIC50: 0.0400nMAssay Description:Experimental objective: to determine the AMP/GMP expression based on fluorescence polarization, i.e., to trace binding of AMP/GMP to antibody so as t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2024
Entry Details
Go to US Patent

TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3B(Human)
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM677025(US11993596, Compound WX055 | US20240294526, Compou...)
Affinity DataIC50: 2.10nMAssay Description:Experimental objective: to determine the AMP/GMP expression based on fluorescence polarization, i.e., to trace binding of AMP/GMP to antibody so as t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2024
Entry Details
Go to US Patent