BDBM677007 US11993596, Compound WX016::US20240294526, Compound WX016

SMILES CCOc1cc2CCn3c(c\c(=N/c4c(C)cc(C)cc4C)n(CCNC(=O)c4cnn[nH]4)c3=O)-c2cc1OC

InChI Key InChIKey=JNEGZALJXCNYJV-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 677007   

TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A(Human)
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM677007(US11993596, Compound WX016 | US20240294526, Compou...)
Affinity DataIC50: 0.0100nMAssay Description:Procedure:1. The recombinant human PDE4B enzyme and enzyme substrate (1 uM cAMP) were each dissolved in newly prepared experimental buffer solution;2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
Go to US Patent

TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Human)
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM677007(US11993596, Compound WX016 | US20240294526, Compou...)
Affinity DataIC50: 0.240nMAssay Description:Procedure:1. The recombinant human PDE4B enzyme and enzyme substrate (1 uM cAMP) were each dissolved in newly prepared experimental buffer solution;2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
Go to US Patent

TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A(Human)
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM677007(US11993596, Compound WX016 | US20240294526, Compou...)
Affinity DataIC50: 0.0100nMAssay Description:Experimental objective: to determine the AMP/GMP expression based on fluorescence polarization, i.e., to trace binding of AMP/GMP to antibody so as t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2024
Entry Details
Go to US Patent

TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3B(Human)
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM677007(US11993596, Compound WX016 | US20240294526, Compou...)
Affinity DataIC50: 0.240nMAssay Description:Experimental objective: to determine the AMP/GMP expression based on fluorescence polarization, i.e., to trace binding of AMP/GMP to antibody so as t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2024
Entry Details
Go to US Patent