BDBM676581 US20240166643, Example 35::US20240166643, Example 84

SMILES CC1CN(CCN1C)c1ncc(F)c(n1)N1CC(C1)C(=O)NC(C)(C)c1cnc2ccccn12

InChI Key InChIKey=GBRQOFYNNFJRTD-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 676581   

TargetGlycylpeptide N-tetradecanoyltransferase 1(Human)
Imperial College Innovations Limited; MyricX Pharma Limited

US Patent
LigandPNGBDBM676581(US20240166643, Example 35 | US20240166643, Example...)
Affinity DataIC50: 0.0160nMAssay Description:The IC50 values of certain Example Compounds of the invention, and for Comparative Examples 1 and 2, for Human NMT1 (HsNMT1) and Plasmodium vivax (Pv...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetGlycylpeptide N-tetradecanoyltransferase(malaria parasite P. vivax)
Imperial College Innovations Limited; MyricX Pharma Limited

US Patent
LigandPNGBDBM676581(US20240166643, Example 35 | US20240166643, Example...)
Affinity DataIC50: 0.00800nMAssay Description:The IC50 values of certain Example Compounds of the invention, and for Comparative Examples 1 and 2, for Human NMT1 (HsNMT1) and Plasmodium vivax (Pv...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetGlycylpeptide N-tetradecanoyltransferase 1(Human)
Imperial College Innovations Limited; MyricX Pharma Limited

US Patent
LigandPNGBDBM676581(US20240166643, Example 35 | US20240166643, Example...)
Affinity DataIC50: 0.0330nMAssay Description:The IC50 values of certain Example Compounds of the invention, and for Comparative Examples 1 and 2, for Human NMT1 (HsNMT1) and Plasmodium vivax (Pv...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetGlycylpeptide N-tetradecanoyltransferase(malaria parasite P. vivax)
Imperial College Innovations Limited; MyricX Pharma Limited

US Patent
LigandPNGBDBM676581(US20240166643, Example 35 | US20240166643, Example...)
Affinity DataIC50: 0.00500nMAssay Description:The IC50 values of certain Example Compounds of the invention, and for Comparative Examples 1 and 2, for Human NMT1 (HsNMT1) and Plasmodium vivax (Pv...More data for this Ligand-Target Pair
In DepthDetails
US Patent