BDBM674716 US20240158368, Compound 63

SMILES CN1CCN(CC1)C(=O)c1cc(Br)cc(c1N1CC[C@H](C1)NC(=O)c1cc(=O)[nH]c2c(F)cccc12)C(F)(F)F

InChI Key InChIKey=ILQFMTFHPOLROO-UHFFFAOYSA-N

Data  5 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 674716   

TargetReplicase polyprotein 1ab(2019-nCoV)
Abbvie

US Patent
LigandPNGBDBM674716(US20240158368, Compound 63)
Affinity DataEC50:  0.560nMAssay Description:SARS-CoV-2 Mpro biochemical assays were performed in 8 μL in 384-well Proxi-Plus plate (PerkinElmer, Waltham, MA USA) at ambient temperature in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2024
Entry Details
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TargetReplicase polyprotein 1ab(HCoV-OC43)
Abbvie

US Patent
LigandPNGBDBM674716(US20240158368, Compound 63)
Affinity DataEC50:  0.910nMAssay Description:SARS-CoV-2 Mpro biochemical assays were performed in 8 μL in 384-well Proxi-Plus plate (PerkinElmer, Waltham, MA USA) at ambient temperature in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2024
Entry Details
Go to US Patent

TargetOrf1a protein(MERS-CoV)
Abbvie

US Patent
LigandPNGBDBM674716(US20240158368, Compound 63)
Affinity DataEC50:  1.06nMAssay Description:SARS-CoV-2 Mpro biochemical assays were performed in 8 μL in 384-well Proxi-Plus plate (PerkinElmer, Waltham, MA USA) at ambient temperature in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2024
Entry Details
Go to US Patent

TargetReplicase polyprotein 1ab(SARS-CoV)
Abbvie

US Patent
LigandPNGBDBM674716(US20240158368, Compound 63)
Affinity DataEC50:  1.27nMAssay Description:SARS-CoV-2 Mpro biochemical assays were performed in 8 μL in 384-well Proxi-Plus plate (PerkinElmer, Waltham, MA USA) at ambient temperature in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2024
Entry Details
Go to US Patent

TargetReplicase polyprotein 1ab(HCoV-229E)
Abbvie

US Patent
LigandPNGBDBM674716(US20240158368, Compound 63)
Affinity DataEC50:  1.99nMAssay Description:SARS-CoV-2 Mpro biochemical assays were performed in 8 μL in 384-well Proxi-Plus plate (PerkinElmer, Waltham, MA USA) at ambient temperature in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2024
Entry Details
Go to US Patent