BDBM669850 (S)-4-(6-(4-(oxetan-3-yl)piperazin-1-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-N-(piperidin-3-yl)-5-(trifluoromethyl)pyrimidine-2-amine ::US20240132489, Compound 24

SMILES FC(F)(F)c1cnc(N[C@H]2CCCNC2)nc1-c1c[nH]c2nc(ccc12)N1CCN(CC1)C1COC1

InChI Key InChIKey=XZHKPDJIOWQMIN-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 669850   

TargetCyclin-H/Cyclin-dependent kinase 7(Human)
Gt Apeiron Therapeutics

US Patent
LigandPNGBDBM669850(US20240132489, Compound 24 | (S)-4-(6-(4-(oxetan-3...)
Affinity DataIC50: 17.4nMAssay Description:The test was performed in a U-shaped bottom 384-well plate (coming, 4512 #), and the reaction temperature was 27° C. CDK7/CyclinH was diluted in a te...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2024
Entry Details
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TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
Gt Apeiron Therapeutics

US Patent
LigandPNGBDBM669850(US20240132489, Compound 24 | (S)-4-(6-(4-(oxetan-3...)
Affinity DataIC50: 8.50E+3nMAssay Description:The test was performed in a U-shaped bottom 384-well plate (coming, 4512 #), and the reaction temperature was 27° C. CDK7/CyclinH was diluted in a te...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2024
Entry Details
Go to US Patent

TargetCyclin-T1/Cyclin-dependent kinase 9(Human)
Gt Apeiron Therapeutics

US Patent
LigandPNGBDBM669850(US20240132489, Compound 24 | (S)-4-(6-(4-(oxetan-3...)
Affinity DataIC50: 5.25E+3nMAssay Description:The test was performed in a U-shaped bottom 384-well plate (coming, 4512 #), and the reaction temperature was 27° C. CDK7/CyclinH was diluted in a te...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2024
Entry Details
Go to US Patent

TargetCyclin-K/Cyclin-dependent kinase 12(Human)
Gt Apeiron Therapeutics

US Patent
LigandPNGBDBM669850(US20240132489, Compound 24 | (S)-4-(6-(4-(oxetan-3...)
Affinity DataIC50: 1.97E+3nMAssay Description:The test was performed in a U-shaped bottom 384-well plate (coming, 4512 #), and the reaction temperature was 27° C. CDK7/CyclinH was diluted in a te...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2024
Entry Details
Go to US Patent