BDBM669832 3-methyl-1-(3-(2-(((S)-piperidin-3-yl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)-1H-pyrrolo[2,3-b]pyridin-6-yl)pyrrolidin-3-ol ::US20240132489, Compound 6

SMILES CC1(O)CCN(C1)c1ccc2c(c[nH]c2n1)-c1nc(N[C@H]2CCCNC2)ncc1C(F)(F)F

InChI Key InChIKey=VYXCNATUHNHTBU-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 669832   

TargetCyclin-H/Cyclin-dependent kinase 7(Human)
Gt Apeiron Therapeutics

US Patent
LigandPNGBDBM669832(US20240132489, Compound 6 | 3-methyl-1-(3-(2-(((S)...)
Affinity DataIC50: 10.4nMAssay Description:The test was performed in a U-shaped bottom 384-well plate (coming, 4512 #), and the reaction temperature was 27° C. CDK7/CyclinH was diluted in a te...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2024
Entry Details
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TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
Gt Apeiron Therapeutics

US Patent
LigandPNGBDBM669832(US20240132489, Compound 6 | 3-methyl-1-(3-(2-(((S)...)
Affinity DataIC50: 4.38E+3nMAssay Description:The test was performed in a U-shaped bottom 384-well plate (coming, 4512 #), and the reaction temperature was 27° C. CDK7/CyclinH was diluted in a te...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2024
Entry Details
Go to US Patent

TargetCyclin-T1/Cyclin-dependent kinase 9(Human)
Gt Apeiron Therapeutics

US Patent
LigandPNGBDBM669832(US20240132489, Compound 6 | 3-methyl-1-(3-(2-(((S)...)
Affinity DataIC50: 1.04E+3nMAssay Description:The test was performed in a U-shaped bottom 384-well plate (coming, 4512 #), and the reaction temperature was 27° C. CDK7/CyclinH was diluted in a te...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2024
Entry Details
Go to US Patent

TargetCyclin-K/Cyclin-dependent kinase 12(Human)
Gt Apeiron Therapeutics

US Patent
LigandPNGBDBM669832(US20240132489, Compound 6 | 3-methyl-1-(3-(2-(((S)...)
Affinity DataIC50: 1.84E+3nMAssay Description:The test was performed in a U-shaped bottom 384-well plate (coming, 4512 #), and the reaction temperature was 27° C. CDK7/CyclinH was diluted in a te...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2024
Entry Details
Go to US Patent