BDBM669254 7-(2-methoxypyridin-4-yl)-5-methyl-6-oxo-8-(4-(4-(trifluoromethoxy)phenoxy)piperidin-1-yl)-5,6-dihydro-1,5-naphthyridine-2-carbonitrile::US11964973, Example 241

SMILES COc1cc(ccn1)-c1c(N2CCC(CC2)Oc2ccc(OC(F)(F)F)cc2)c2nc(ccc2n(C)c1=O)C#N

InChI Key InChIKey=HDTINQXBFIARKY-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 669254   

TargetDiacylglycerol kinase alpha(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM669254(7-(2-methoxypyridin-4-yl)-5-methyl-6-oxo-8-(4-(4-(...)
Affinity DataIC50: 58nMAssay Description:The DGKα and DGKζ reactions were performed using either extruded liposome (DGKα and DGKζ LIPGLO assays). The reactions were carri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/13/2024
Entry Details
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TargetDiacylglycerol kinase zeta(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM669254(7-(2-methoxypyridin-4-yl)-5-methyl-6-oxo-8-(4-(4-(...)
Affinity DataIC50: 2.20E+4nMAssay Description:The DGKα and DGKζ reactions were performed using either extruded liposome (DGKα and DGKζ LIPGLO assays). The reactions were carri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/13/2024
Entry Details
Go to US Patent