BDBM668214 US20240124450, Example 53

SMILES CNc1ccc2ncc(-c3cc(OCC4(N)CCCC4)c(C#N)c(SC)c3)n2c1C#N

InChI Key InChIKey=AWLHPMOLJAWKDL-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 668214   

TargetSerine/threonine-protein kinase SIK1(Human)
Pfizer

US Patent
LigandPNGBDBM668214(US20240124450, Example 53)
Affinity DataIC50: 0.100nMAssay Description:Salt Induced Kinase (SIK) activity is determined by measuring the effect of a test agent on the activity of the appropriate SIK enzyme to phosphoryla...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2024
Entry Details
Go to US Patent

TargetSerine/threonine-protein kinase SIK2(Human)
Pfizer

US Patent
LigandPNGBDBM668214(US20240124450, Example 53)
Affinity DataIC50: 0.400nMAssay Description:Salt Induced Kinase (SIK) activity is determined by measuring the effect of a test agent on the activity of the appropriate SIK enzyme to phosphoryla...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2024
Entry Details
Go to US Patent

TargetSerine/threonine-protein kinase SIK3(Human)
Pfizer

US Patent
LigandPNGBDBM668214(US20240124450, Example 53)
Affinity DataIC50: 1.5nMAssay Description:Salt Induced Kinase (SIK) activity is determined by measuring the effect of a test agent on the activity of the appropriate SIK enzyme to phosphoryla...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2024
Entry Details
Go to US Patent