BDBM663833 US20240109915, Example 14

SMILES CCOc1cc(cc2c(C)nn(C)c12)C(=O)N1CCC2(CC1)Cc1sc(nc1C(=O)C2)C(C)(C)C

InChI Key InChIKey=YDEJDFWIPXRWCS-UHFFFAOYSA-N

Data  2 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 663833   

TargetAcetyl-CoA carboxylase 1(Human)
Smith, Gambrell & Russell

Curated by ChEMBL

LigandBDBM663833(US20240109915, Example 14)Copy SMILESCopy InChI

Affinity DataIC50: 2.20nMAssay Description:Inhibition of full length human recombinant ACC1 expressed in baculovirus infected Sf9 cells incubated for 18 hrs in presence of ATP by envision fluo...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
12/16/2024
Entry Details
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TargetActivating signal cointegrator 1 complex subunit 1(Human)
Pfizer

US Patent

LigandBDBM663833(US20240109915, Example 14)Copy SMILESCopy InChI

Affinity DataIC50: 2.20nMAssay Description:The ACC inhibitory activity of the compounds of the present invention was demonstrated by methods based on standard procedures. The direct inhibition...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
6/20/2024
Entry Details
Copy Entry DOIGo to US Patent

Copy Rxn URL