BDBM663072 2-((S)-4-(7-(8- chloronaphthalen-1- yl)-8-fluoro- 2-((S)-1-methylpyrrolidin-2- yl)methoxy)quinazolin- 4-yl)-1-(2- fluoroacryloyl)piperazin- 2-yl)acetonitrile::US20240109893, Example 903

SMILES CN1CCC[C@H]1COc1nc(N2CCN([C@@H](CC#N)C2)C(=O)C(F)=C)c2ccc(c(F)c2n1)-c1cccc2cccc(Cl)c12

InChI Key InChIKey=GSHWNCGMCRCTLO-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 663072   

TargetGTPase KRas [G12C](Human)
Shanghai Kechow Pharma

US Patent
LigandPNGBDBM663072(2-((S)-4-(7-(8- chloronaphthalen-1- yl)-8-fluoro- ...)
Affinity DataIC50: 0.890nMAssay Description:1. Serially 4×-diluted compounds (10 concentration points in total) were separately premixed with KRAS G12C-GDP (ICE, Kras 20191018) in a reaction bu...More data for this Ligand-Target Pair
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Date in BDB:
6/20/2024
Entry Details
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