BDBM663060 2-((S)-1-acryloyl-4-(6-fluoro-7-(8-chloronaphthalen-1- yl)-2-(((S)-1-methylpyrrolidin-2- yl)methoxy)quinazolin-4-yl)piperazin-2-yl)acetonitrile::US20240109893, Example 394

SMILES CN1CCC[C@H]1COc1nc(N2CCN([C@@H](CC#N)C2)C(=O)C=C)c2cc(F)c(cc2n1)-c1cccc2cccc(Cl)c12

InChI Key InChIKey=HJURXPGGRCZIME-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 663060   

TargetGTPase KRas [G12C](Human)
Shanghai Kechow Pharma

US Patent
LigandPNGBDBM663060(2-((S)-1-acryloyl-4-(6-fluoro-7-(8-chloronaphthale...)
Affinity DataIC50: 1.44nMAssay Description:1. Serially 4×-diluted compounds (10 concentration points in total) were separately premixed with KRAS G12C-GDP (ICE, Kras 20191018) in a reaction bu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2024
Entry Details
Go to US Patent