BDBM663058 2-((S)-1-acryloyl-4-(2-(((S)-1-methylpyrrolidin-2- yl)methoxy)-7-(5,6,7,8-tetrahydronaphthalen-1- yl)pyridino[2,3-d]pyrimidin-4-yl)piperazin-2- yl)acetonitrile::US20240109893, Example 286

SMILES CN1CCC[C@H]1COc1nc(N2CCN([C@@H](CC#N)C2)C(=O)C=C)c2ccc(nc2n1)-c1cccc2CCCCc12

InChI Key InChIKey=LLGATNIKVJLCDJ-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 663058   

TargetGTPase KRas [G12C](Human)
Shanghai Kechow Pharma

US Patent
LigandPNGBDBM663058(2-((S)-1-acryloyl-4-(2-(((S)-1-methylpyrrolidin-2-...)
Affinity DataIC50: 9.91nMAssay Description:1. Serially 4×-diluted compounds (10 concentration points in total) were separately premixed with KRAS G12C-GDP (ICE, Kras 20191018) in a reaction bu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2024
Entry Details
Go to US Patent