BDBM663055 2-((S)-1-acryloyl-4-(8-fluoro-7-(4-fluoro-5,6,7,8- tetrahydronaphthalen-1-yl)-2-(((S)-1- methylpyrrolidin-2-yl)methoxy)pyridino[4,3- d]pyrimidin-4-yl)piperazin-2-yl)acetonitrile::US20240109893, Example 17

SMILES CN1CCC[C@H]1COc1nc(N2CCN([C@@H](CC#N)C2)C(=O)C=C)c2cnc(c(F)c2n1)-c1ccc(F)c2CCCCc12

InChI Key InChIKey=DERDFDCRLVAOTB-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 663055   

TargetGTPase KRas [G12C](Human)
Shanghai Kechow Pharma

US Patent
LigandPNGBDBM663055(2-((S)-1-acryloyl-4-(8-fluoro-7-(4-fluoro-5,6,7,8-...)
Affinity DataIC50: 1.65nMAssay Description:1. Serially 4×-diluted compounds (10 concentration points in total) were separately premixed with KRAS G12C-GDP (ICE, Kras 20191018) in a reaction bu...More data for this Ligand-Target Pair
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Date in BDB:
6/20/2024
Entry Details
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