BDBM661151 3-(6-fluoropyridin-3-yl)-6-(1-methyl- 1H-pyrazol-4-yl)-2-[4-(4-methyl-4H- 1,2,4-triazol-3-yl)piperidin-1- yl]benzonitrile::US20240101544, Example 35::US20240101544, Example 54

SMILES Cn1cc(cn1)-c1ccc(-c2ccc(F)nc2)c(N2CCC(CC2)c2nncn2C)c1C#N

InChI Key InChIKey=CQACQHWCNMREGO-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 661151   

LigandPNGBDBM661151(US20240101544, Example 35 | US20240101544, Example...)
Affinity DataIC50: 100nMAssay Description:Compound IC50 values for the inhibition of QPCTL activity were determined using a biochemical fluorescent-based assay. QPCTL activity was measured in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2024
Entry Details
Go to US Patent

TargetGlutaminyl-peptide cyclotransferase(Human)
TBA

US Patent
LigandPNGBDBM661151(US20240101544, Example 35 | US20240101544, Example...)
Affinity DataIC50: 100nMAssay Description:Compound IC50 values for the inhibition of QPCT (rhQPCT, R&D Systems) activity were determined using a biochemical fluorescent-based assay. QPCT acti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2024
Entry Details
Go to US Patent

LigandPNGBDBM661151(US20240101544, Example 35 | US20240101544, Example...)
Affinity DataIC50: 100nMAssay Description:Compound IC50 values for the inhibition of QPCTL activity were determined using a biochemical fluorescent-based assay. QPCTL activity was measured in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2024
Entry Details
Go to US Patent

TargetGlutaminyl-peptide cyclotransferase(Human)
TBA

US Patent
LigandPNGBDBM661151(US20240101544, Example 35 | US20240101544, Example...)
Affinity DataIC50: 100nMAssay Description:Compound IC50 values for the inhibition of QPCT (rhQPCT, R&D Systems) activity were determined using a biochemical fluorescent-based assay. QPCT acti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2024
Entry Details
Go to US Patent