BDBM656521 US11919887, Compound 52::rel-(2R,3S,4S,5R)-N-(3-carbamoylpheny1)-3-[2-(difluoromethoxy)-3,4-difluoro-phenyl]-4,5-dimethyl-5-(trifluoromethyl)tetrahydrofuran-2-carboxamide

SMILES C[C@H]1[C@H]([C@@H](O[C@@]1(C)C(F)(F)F)C(=O)Nc1cccc(c1)C(N)=O)c1ccc(F)c(F)c1OC(F)F

InChI Key InChIKey=CUCKWBCZSYAYTR-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 656521   

TargetSodium channel protein type 5 subunit alpha(Human)
Vertex Pharmaceuticals

US Patent
LigandPNGBDBM656521(US11919887, Compound 52 | rel-(2R,3S,4S,5R)-N-(3-c...)
Affinity DataIC50: 10nMAssay Description:Assay Protocol (7 Key Steps):1) To reach the final concentration in each well, 400 nL of each compound was pre-spotted (in neat DMSO) into polypropyl...More data for this Ligand-Target Pair
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Date in BDB:
5/17/2024
Entry Details
Go to US Patent