BDBM656519 US11919887, Compound 47::rel-(2R,3S,5R)-N-(3-carbamoyl-4-fluoro-phenyl)-3-(3,4-difluoro-2-methoxy-phenyl)-5-methyl-5-(trifluoromethyl)tetrahydrofuran-2-carboxamide

SMILES COc1c(F)c(F)ccc1[C@@H]1C[C@@](C)(O[C@H]1C(=O)Nc1ccc(F)c(c1)C(N)=O)C(F)(F)F

InChI Key InChIKey=MHAVSQYZESWCGI-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 656519   

TargetSodium channel protein type 5 subunit alpha(Human)
Vertex Pharmaceuticals

US Patent
LigandPNGBDBM656519(US11919887, Compound 47 | rel-(2R,3S,5R)-N-(3-carb...)
Affinity DataIC50: 55nMAssay Description:Assay Protocol (7 Key Steps):1) To reach the final concentration in each well, 400 nL of each compound was pre-spotted (in neat DMSO) into polypropyl...More data for this Ligand-Target Pair
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Date in BDB:
5/17/2024
Entry Details
Go to US Patent