BDBM656491 US11919887, Compound 17::US11919887, Compound 53::rel-(2S,3R,4R,5S)-4-[[3-[2-(difluoromethoxy)-4-fluoro-3-methyl-phenyl]-4,5-dimethyl-5-(trifluoromethyl)tetrahydrofuran-2-carbonyl]amino]pyridine-2-carboxamide

SMILES C[C@@H]1[C@@H]([C@H](O[C@]1(C)C(F)(F)F)C(=O)Nc1ccnc(c1)C(N)=O)c1ccc(F)c(C)c1OC(F)F

InChI Key InChIKey=BCMPVFJLPUNIGA-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 656491   

TargetSodium channel protein type 5 subunit alpha(Human)
Vertex Pharmaceuticals

US Patent
LigandPNGBDBM656491(US11919887, Compound 17 | US11919887, Compound 53 ...)
Affinity DataIC50: 10nMAssay Description:Assay Protocol (7 Key Steps):1) To reach the final concentration in each well, 400 nL of each compound was pre-spotted (in neat DMSO) into polypropyl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2024
Entry Details
Go to US Patent

TargetSodium channel protein type 5 subunit alpha(Human)
Vertex Pharmaceuticals

US Patent
LigandPNGBDBM656491(US11919887, Compound 17 | US11919887, Compound 53 ...)
Affinity DataIC50: 10nMAssay Description:Assay Protocol (7 Key Steps):1) To reach the final concentration in each well, 400 nL of each compound was pre-spotted (in neat DMSO) into polypropyl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2024
Entry Details
Go to US Patent