BDBM655514 US11912714, Example 11

SMILES CC(C)(C)C[C@H](NC(=O)C(C)(C)C(=O)Nc1cc(F)ccc1F)C(=O)N1C[C@]2(C[C@H]1C#N)C(=O)Nc1ccccc21

InChI Key InChIKey=ONPRPAUVJBVMMG-UHFFFAOYSA-N

Data  1 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 655514   

TargetReplicase polyprotein 1ab(2019-nCoV)
Enanta Pharmaceuticals

US Patent
LigandPNGBDBM655514(US11912714, Example 11)
Affinity DataIC50: 100nMAssay Description:Recombinant SARS-CoV-2 3CL-protease was expressed and purified. TAMRA-SITSAVLQSGFRKMK-Dabcyl-OH peptide 3CLpro substrate was synthesized. Black, low ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2024
Entry Details
Go to US Patent

TargetReplicase polyprotein 1ab(HCoV-229E)
Enanta Pharmaceuticals

US Patent
LigandPNGBDBM655514(US11912714, Example 11)
Affinity DataEC50:  550nMAssay Description:384-well black cell-culture-treated plastic clear-bottom plates are used in this assay. Using an ECHO liquid dispenser, 3-fold serial dilutions of co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2024
Entry Details
Go to US Patent