BDBM653473 (P)-(7S)-4-(2-methylphenyl)-7-(4-methyl- 1,3-thiazol-5-yl)-2-(2-(2-propenoyl)-2,6- diazaspiro[3.4]octan-6-yl)-5,6,7,8- tetrahydro-3-quinolinecarbonitrile (3rd eluting isomer)::US20240059703, Example 23-4::US20240059703, Example 23-6
SMILES Cc1ncsc1[C@H]1CCc2c(C1)nc(N1CCC3(CN(C3)C(=O)C=C)C1)c(C#N)c2-c1ccccc1C
InChI Key InChIKey=VZOIBBRJWWMLSQ-UHFFFAOYSA-N
Data 2 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 2 hits for monomerid = 653473
Affinity DataIC50: 19nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
Affinity DataIC50: 128nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair