BDBM653301 1-(6-((1R,9R)-5-fluoro- 10,10-dimethyl-6-(5- methyl-1H-indazol-4- yl)-3- azatricyclo[7.1.1.02,7] undeca-2,4,6-trien-4-yl)-2,6- diazaspiro[3.4]octan-2- yl)-2-propen-1-one::US20240059703, Example 14-72::US20240059703, Example 14-73::US20240059703, Example 14-74

SMILES Cc1ccc2[nH]ncc2c1-c1c(F)c(nc2[C@@H]3C[C@H](Cc12)C3(C)C)N1CCC2(CN(C2)C(=O)C=C)C1

InChI Key InChIKey=XEXKHEPHFWFQLK-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 653301   

LigandPNGBDBM653301(US20240059703, Example 14-72 | 1-(6-((1R,9R)-5-flu...)
Affinity DataIC50: 30nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM653301(US20240059703, Example 14-72 | 1-(6-((1R,9R)-5-flu...)
Affinity DataIC50: 10nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM653301(US20240059703, Example 14-72 | 1-(6-((1R,9R)-5-flu...)
Affinity DataIC50: 1.56E+3nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
In DepthDetails
US Patent