BDBM653277 (1R,9R)-10,10-dimethyl- 6-(6-methyl-1H-indazol- 7-yl)-4-(2-(2- propenoyl)-2,6- diazaspiro[3.4]octan-6- yl)-3- azatricyclo[7.1.1.02,7] undeca-2,4,6-triene-5- carbonitrile::US20240059703, Example 14-48::US20240059703, Example 14-51::US20240059703, Example 14-52

SMILES Cc1ccc2cn[nH]c2c1-c1c2C[C@H]3C[C@@H](c2nc(N2CCC4(CN(C4)C(=O)C=C)C2)c1C#N)C3(C)C

InChI Key InChIKey=QEXSSKIOJWZKAA-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 653277   

LigandPNGBDBM653277(US20240059703, Example 14-48 | US20240059703, Exam...)
Affinity DataIC50: 61nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM653277(US20240059703, Example 14-48 | US20240059703, Exam...)
Affinity DataIC50: 11nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM653277(US20240059703, Example 14-48 | US20240059703, Exam...)
Affinity DataIC50: 1.02E+3nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
In DepthDetails
US Patent