BDBM653015 8-(5-chloro-1,6- dimethyl-1H- indazol-7-yl)-6- ((5S)-5-methyl- 2-(2-propenoyl)- 2,6- diazaspiro[3.4] octan-6-yl)-3,4- dihydro-2H- chromene-7- carbonitrile::US20240059703, Example 2-107

SMILES C[C@@H]1N(CCC11CN(C1)C(=O)C=C)c1cc2CCCOc2c(c1C#N)-c1c(C)c(Cl)cc2cnn(C)c12

InChI Key InChIKey=YQWYZXLJKULFRX-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 653015   

LigandPNGBDBM653015(US20240059703, Example 2-107 | 8-(5-chloro-1,6- di...)
Affinity DataIC50: 17nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
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