BDBM652817 US20240059694, Compound I-1

SMILES Nc1ncnc2n(nc(-c3ccc(NC(=O)c4ccccc4)c4OCOc34)c12)[C@@H]1CCCN(C1)C(=O)C=C

InChI Key InChIKey=ABNIYONJQKWVCA-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 652817   

TargetTyrosine-protein kinase BTK(Human)
Xi'An Xintong Pharmaceutical Research

US Patent
LigandPNGBDBM652817(US20240059694, Compound I-1)
Affinity DataIC50: 25nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2024
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK3(Human)
Xi'An Xintong Pharmaceutical Research

US Patent
LigandPNGBDBM652817(US20240059694, Compound I-1)
Affinity DataIC50: 275nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2024
Entry Details
Go to US Patent

TargetTyrosine-protein kinase BTK(Human)
Xi'An Xintong Pharmaceutical Research

US Patent
LigandPNGBDBM652817(US20240059694, Compound I-1)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of BTK (unknown origin) preincubated for 10 mins followed by kinase substrate and ATP addition and measured for 20 mins by mobility shift ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Xi'An Xintong Pharmaceutical Research

US Patent
LigandPNGBDBM652817(US20240059694, Compound I-1)
Affinity DataIC50: 73nMAssay Description:Inhibition of JAK3 (unknown origin) preincubated for 10 mins followed by kinase substrate and ATP addition and measured for 30 mins by mobility shift...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed