BDBM652690 4-chloro-6-N-{[2-({2-methyl-5H,6H,7H,8H-imidazo[1,2-a]pyridin-7-yl}methoxy)pyridin-4- yl]methyl}isoquinoline-1,6-diamine::US20240059691, Example 4309

SMILES Cc1cn2CCC(COc3cc(CNc4ccc5c(N)ncc(Cl)c5c4)ccn3)Cc2n1

InChI Key InChIKey=CSNSELBEUILYAV-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 652690   

TargetCoagulation factor XII(Human)
Kalvista Pharmaceuticals

US Patent
LigandPNGBDBM652690(US20240059691, Example 4309 | 4-chloro-6-N-{[2-({2...)
Affinity DataIC50: 200nMAssay Description:In vitro inhibition of Factor XIIa was determined using an IC50 assay based on standard literature methods (see e.g Baeriswyl et al., ACS Chem. Biol....More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2024
Entry Details
Go to US Patent

TargetPlasma kallikrein(Human)
Kalvista Pharmaceuticals

US Patent
LigandPNGBDBM652690(US20240059691, Example 4309 | 4-chloro-6-N-{[2-({2...)
Affinity DataIC50: 1nMAssay Description:In vitro inhibition of related proteases was determined using an (C50 assay based on standard literature methods (see e.g. Shori et al., Biochem. Pha...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2024
Entry Details
Go to US Patent