BDBM652618 N6-(2-fluoro-4-((((4R*,5R*)-2-methyl-2-azabicyclo[2.2.1]heptan-5- yl)oxy)methyl)benzyl)isoquinoline-1,6-diamine::US20240059691, Example 2198

SMILES CN1C[C@H]2CC1C[C@H]2OCc1ccc(CNc2ccc3c(N)nccc3c2)c(F)c1

InChI Key InChIKey=CYDSMQBZTXOTJO-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 652618   

TargetCoagulation factor XII(Human)
Kalvista Pharmaceuticals

US Patent
LigandPNGBDBM652618(US20240059691, Example 2198 | N6-(2-fluoro-4-((((4...)
Affinity DataIC50: 200nMAssay Description:In vitro inhibition of Factor XIIa was determined using an IC50 assay based on standard literature methods (see e.g Baeriswyl et al., ACS Chem. Biol....More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2024
Entry Details
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TargetPlasma kallikrein(Human)
Kalvista Pharmaceuticals

US Patent
LigandPNGBDBM652618(US20240059691, Example 2198 | N6-(2-fluoro-4-((((4...)
Affinity DataIC50: 6.50E+3nMAssay Description:In vitro inhibition of related proteases was determined using an (C50 assay based on standard literature methods (see e.g. Shori et al., Biochem. Pha...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2024
Entry Details
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TargetCoagulation factor X(Human)
Kalvista Pharmaceuticals

US Patent
LigandPNGBDBM652618(US20240059691, Example 2198 | N6-(2-fluoro-4-((((4...)
Affinity DataIC50: 6.50E+3nMAssay Description:In vitro inhibition of related proteases was determined using an (C50 assay based on standard literature methods (see e.g. Shori et al., Biochem. Pha...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2024
Entry Details
Go to US Patent

TargetCoagulation factor XI(Human)
Kalvista Pharmaceuticals

US Patent
LigandPNGBDBM652618(US20240059691, Example 2198 | N6-(2-fluoro-4-((((4...)
Affinity DataIC50: 2nMAssay Description:In vitro inhibition of related proteases was determined using an (C50 assay based on standard literature methods (see e.g. Shori et al., Biochem. Pha...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2024
Entry Details
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TargetProthrombin(Human)
Kalvista Pharmaceuticals

US Patent
LigandPNGBDBM652618(US20240059691, Example 2198 | N6-(2-fluoro-4-((((4...)
Affinity DataIC50: 2.50E+4nMAssay Description:In vitro inhibition of related proteases was determined using an (C50 assay based on standard literature methods (see e.g. Shori et al., Biochem. Pha...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2024
Entry Details
Go to US Patent