BDBM649749 (E)-2-fluoro-6-(((4- methylpiperazin-1- yl)imino)methyl)-4-(3-(6- (pyrrolidin-1-yl)pyridin-3-yl)- 1,2,4-thiadiazol-5-yl)phenol::US20240043395, Compound 165

SMILES CN1CCN(CC1)\N=C\c1cc(cc(F)c1O)-c1nc(ns1)-c1ccc(nc1)N1CCCC1

InChI Key InChIKey=ZTACONYFETWDLI-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 649749   

TargetToll-like receptor 2(Human)
Neuropore Therapies

US Patent
LigandPNGBDBM649749((E)-2-fluoro-6-(((4- methylpiperazin-1- yl)imino)m...)
Affinity DataIC50: 1.10E+3nMAssay Description:On day 1, 50 μL of each test compound dilution in duplicates or a vehicle control was added to each well of a 96-well plate followed by addition...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/12/2024
Entry Details
Go to US Patent

TargetToll-like receptor 6(Human)
Neuropore Therapies

US Patent
LigandPNGBDBM649749((E)-2-fluoro-6-(((4- methylpiperazin-1- yl)imino)m...)
Affinity DataIC50: 900nMAssay Description:On day 1, 50 μL of each test compound dilution in duplicates or a vehicle control was added to each well of a 96-well plate followed by addition...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/12/2024
Entry Details
Go to US Patent

TargetToll-like receptor 9(Human)
Neuropore Therapies

US Patent
LigandPNGBDBM649749((E)-2-fluoro-6-(((4- methylpiperazin-1- yl)imino)m...)
Affinity DataIC50: 410nMAssay Description:On day 1, 50 μL of each test compound dilution in duplicates or a vehicle control was added to each well of a 96-well plate followed by addition...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/12/2024
Entry Details
Go to US Patent