BDBM649747 (3-fluoro-4-hydroxy-5-(((4- methylpiperazin-1- yl)imino)methyl)phenyl)(4-(4- (pyrrolidin-1- yl)phenyl)piperidin-1- yl)methanone::US20240043395, Compound 163

SMILES CN1CCN(CC1)\N=C\c1cc(cc(F)c1O)C(=O)N1CCC(CC1)c1ccc(cc1)N1CCCC1

InChI Key InChIKey=LEZNYGQGMZHAKH-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 649747   

TargetToll-like receptor 2(Human)
Neuropore Therapies

US Patent
LigandPNGBDBM649747((3-fluoro-4-hydroxy-5-(((4- methylpiperazin-1- yl)...)
Affinity DataIC50: 600nMAssay Description:On day 1, 50 μL of each test compound dilution in duplicates or a vehicle control was added to each well of a 96-well plate followed by addition...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/12/2024
Entry Details
Go to US Patent

TargetToll-like receptor 6(Human)
Neuropore Therapies

US Patent
LigandPNGBDBM649747((3-fluoro-4-hydroxy-5-(((4- methylpiperazin-1- yl)...)
Affinity DataIC50: 400nMAssay Description:On day 1, 50 μL of each test compound dilution in duplicates or a vehicle control was added to each well of a 96-well plate followed by addition...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/12/2024
Entry Details
Go to US Patent

TargetToll-like receptor 9(Human)
Neuropore Therapies

US Patent
LigandPNGBDBM649747((3-fluoro-4-hydroxy-5-(((4- methylpiperazin-1- yl)...)
Affinity DataIC50: 260nMAssay Description:On day 1, 50 μL of each test compound dilution in duplicates or a vehicle control was added to each well of a 96-well plate followed by addition...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/12/2024
Entry Details
Go to US Patent