BDBM647637 US20240025908, Example 5

SMILES C[C@@H](Nc1ccn2ncc(C3=NN=CC(C)(C)N3)c2n1)c1cc(F)cc(F)c1F

InChI Key InChIKey=ARFSIMCXZSKBGL-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 647637   

TargetProto-oncogene tyrosine-protein kinase ROS(Human)
Tyk Medicines

US Patent
LigandPNGBDBM647637(US20240025908, Example 5)
Affinity DataIC50: 2.75nMAssay Description:Inhibition of protein kinase activity by compounds was carried out on the Radio-tagged HotSpot kinase experimental platform of Reaction Biology Corpo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2024
Entry Details
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TargetProto-oncogene tyrosine-protein kinase ROS [G2032R](Human)
Tyk Medicines

US Patent
LigandPNGBDBM647637(US20240025908, Example 5)
Affinity DataIC50: 27.5nMAssay Description:Inhibition of protein kinase activity by compounds was carried out on the Radio-tagged HotSpot kinase experimental platform of Reaction Biology Corpo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2024
Entry Details
Go to US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Tyk Medicines

US Patent
LigandPNGBDBM647637(US20240025908, Example 5)
Affinity DataIC50: 2.75nMAssay Description:Inhibition of protein kinase activity by compounds was carried out on the Radio-tagged HotSpot kinase experimental platform of Reaction Biology Corpo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2024
Entry Details
Go to US Patent

TargetHigh affinity nerve growth factor receptor [G667C](Human)
Tyk Medicines

US Patent
LigandPNGBDBM647637(US20240025908, Example 5)
Affinity DataIC50: 27.5nMAssay Description:Inhibition of protein kinase activity by compounds was carried out on the Radio-tagged HotSpot kinase experimental platform of Reaction Biology Corpo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2024
Entry Details
Go to US Patent

TargetALK tyrosine kinase receptor(Human)
Tyk Medicines

US Patent
LigandPNGBDBM647637(US20240025908, Example 5)
Affinity DataIC50: 27.5nMAssay Description:Inhibition of protein kinase activity by compounds was carried out on the Radio-tagged HotSpot kinase experimental platform of Reaction Biology Corpo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2024
Entry Details
Go to US Patent

TargetALK tyrosine kinase receptor [G1202R](Human)
Tyk Medicines

US Patent
LigandPNGBDBM647637(US20240025908, Example 5)
Affinity DataIC50: 27.5nMAssay Description:Inhibition of protein kinase activity by compounds was carried out on the Radio-tagged HotSpot kinase experimental platform of Reaction Biology Corpo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2024
Entry Details
Go to US Patent