BDBM647345 US20240025892, Example 52

SMILES CCn1cc(cn1)-c1ccc2c(cnn2c1)-c1ccc(cc1)C#N

InChI Key InChIKey=KAUKMJZXRPFGAB-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 647345   

TargetSerine/threonine-protein kinase SIK2(Human)
The General Hospital

US Patent
LigandPNGBDBM647345(US20240025892, Example 52)
Affinity DataIC50: 1.11nMAssay Description:Assays were performed in base reaction buffer (20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/mL BSA, 0.1 mM Na3VO4, 2 mM DTT, 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2024
Entry Details
Go to US Patent

TargetSerine/threonine-protein kinase SIK3(Human)
The General Hospital

US Patent
LigandPNGBDBM647345(US20240025892, Example 52)
Affinity DataIC50: 1.64nMAssay Description:Assays were performed in base reaction buffer (20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/mL BSA, 0.1 mM Na3VO4, 2 mM DTT, 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2024
Entry Details
Go to US Patent

TargetSerine/threonine-protein kinase SIK1(Human)
The General Hospital

US Patent
LigandPNGBDBM647345(US20240025892, Example 52)
Affinity DataIC50: 4.77nMAssay Description:Assays were performed in base reaction buffer (20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/mL BSA, 0.1 mM Na3VO4, 2 mM DTT, 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2024
Entry Details
Go to US Patent