BDBM647344 US20240025892, Example 51

SMILES CCc1nnc(o1)-c1c(OC)cc(cc1OC)-c1cnc2cc(ccn12)-c1cnn(C)c1

InChI Key InChIKey=VOYZWDQJVPQGCO-UHFFFAOYSA-N

Data  15 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 647344   

TargetSerine/threonine-protein kinase SIK2(Human)
The General Hospital

US Patent
LigandPNGBDBM647344(US20240025892, Example 51)
Affinity DataIC50: 0.412nMAssay Description:Assays were performed in base reaction buffer (20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/mL BSA, 0.1 mM Na3VO4, 2 mM DTT, 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2024
Entry Details
Go to US Patent

TargetSerine/threonine-protein kinase SIK3(Human)
The General Hospital

US Patent
LigandPNGBDBM647344(US20240025892, Example 51)
Affinity DataIC50: 1.18nMAssay Description:Assays were performed in base reaction buffer (20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/mL BSA, 0.1 mM Na3VO4, 2 mM DTT, 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2024
Entry Details
Go to US Patent

TargetSerine/threonine-protein kinase SIK1(Human)
The General Hospital

US Patent
LigandPNGBDBM647344(US20240025892, Example 51)
Affinity DataIC50: 6.49nMAssay Description:Assays were performed in base reaction buffer (20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/mL BSA, 0.1 mM Na3VO4, 2 mM DTT, 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2024
Entry Details
Go to US Patent

TargetSerine/threonine-protein kinase SIK1(Human)
The General Hospital

US Patent
LigandPNGBDBM647344(US20240025892, Example 51)
Affinity DataIC50: 6.5nMAssay Description:Inhibition of Nano-Luc fused full length recombinant SIK1 (unknown origin) transfected in HEK293 cells using AMARAASAAALARRR as substrate incubated f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetSerine/threonine-protein kinase SIK2(Human)
The General Hospital

US Patent
LigandPNGBDBM647344(US20240025892, Example 51)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of Nano-Luc fused full length recombinant SIK2 (unknown origin) transfected in HEK293 cells using AMARAASAAALARRR as substrate incubated f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetSerine/threonine-protein kinase SIK3(Human)
The General Hospital

US Patent
LigandPNGBDBM647344(US20240025892, Example 51)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of Nano-Luc fused full length recombinant SIK3 (unknown origin) transfected in HEK293 cells using AMARAASAAALARRR as substrate incubated f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
LigandPNGBDBM647344(US20240025892, Example 51)
Affinity DataIC50: 15nMAssay Description:Inhibition of human recombinant PDGFRalpha by microfluidic mobility shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetTyrosine-protein kinase CSK(Human)
Galapagos

Curated by ChEMBL
LigandPNGBDBM647344(US20240025892, Example 51)
Affinity DataIC50: 54nMAssay Description:Inhibition of human recombinant CSK by microfluidic mobility shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetTRAF2 and NCK-interacting protein kinase(Human)
Galapagos

Curated by ChEMBL
LigandPNGBDBM647344(US20240025892, Example 51)
Affinity DataIC50: 56nMAssay Description:Inhibition of human recombinant TNIK by microfluidic mobility shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetSerine/threonine-protein kinase TBK1(Human)
Galapagos

Curated by ChEMBL
LigandPNGBDBM647344(US20240025892, Example 51)
Affinity DataIC50: 67nMAssay Description:Inhibition of human recombinant TBK1 by microfluidic mobility shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
LigandPNGBDBM647344(US20240025892, Example 51)
Affinity DataIC50: 70nMAssay Description:Inhibition of human recombinant IKKepsilon by microfluidic mobility shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetTyrosine-protein kinase ABL1(Human)
Galapagos

Curated by ChEMBL
LigandPNGBDBM647344(US20240025892, Example 51)
Affinity DataIC50: 72nMAssay Description:Inhibition of human recombinant ABL1 by microfluidic mobility shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetSerine/threonine-protein kinase SIK1(Human)
The General Hospital

US Patent
LigandPNGBDBM647344(US20240025892, Example 51)
Affinity DataIC50: 6.5nMAssay Description:Inhibition of SIK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetSerine/threonine-protein kinase SIK2(Human)
The General Hospital

US Patent
LigandPNGBDBM647344(US20240025892, Example 51)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of SIK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetSerine/threonine-protein kinase SIK3(Human)
The General Hospital

US Patent
LigandPNGBDBM647344(US20240025892, Example 51)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of SIK3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed