BDBM646012 (2S,4R)-4-hydroxy-N-[[4-(5-methyl-1,3- thiazol-4-yl)phenyl]methyl]-1-[(2S)-2-[[2-[4- (2-hydroxyphenyl)-1,5,6,8,12- pentazatricyclo[8.4.0.02,7]tetradeca-2,4,6- trien-12-yl]acetyl]amino]-3,3- dimethylbutanoyl]pyrrolidine-2-carboxamide (Diastereomer 1 - *)::US20240018158, Example 2a::US20240018158, Example 2b

SMILES Cc1scnc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CN2CCN3C(CNc4nnc(cc34)-c3ccccc3O)C2)C(C)(C)C)cc1

InChI Key InChIKey=HCMYOXQNMXWNNB-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 646012   

TargetProbable global transcription activator SNF2L2(Human)
Prelude Therapeutics

US Patent
LigandPNGBDBM646012(US20240018158, Example 2b | (2S,4R)-4-hydroxy-N-[[...)
Affinity DataIC50: 550nMAssay Description:The inhibitory activity of compounds was evaluated in vitro using TR-FRET assay with white 384-well low volume microplate (PerkinElmer ProxiPlate Plu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2024
Entry Details
Go to US Patent

TargetTranscription activator BRG1(Human)
Prelude Therapeutics

US Patent
LigandPNGBDBM646012(US20240018158, Example 2b | (2S,4R)-4-hydroxy-N-[[...)
Affinity DataIC50: 550nMAssay Description:The inhibitory activity of compounds was evaluated in vitro using TR-FRET assay with white 384-well low volume microplate (PerkinElmer ProxiPlate Plu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2024
Entry Details
Go to US Patent

TargetProbable global transcription activator SNF2L2(Human)
Prelude Therapeutics

US Patent
LigandPNGBDBM646012(US20240018158, Example 2b | (2S,4R)-4-hydroxy-N-[[...)
Affinity DataIC50: 100nMAssay Description:The inhibitory activity of compounds was evaluated in vitro using TR-FRET assay with white 384-well low volume microplate (PerkinElmer ProxiPlate Plu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2024
Entry Details
Go to US Patent

TargetTranscription activator BRG1(Human)
Prelude Therapeutics

US Patent
LigandPNGBDBM646012(US20240018158, Example 2b | (2S,4R)-4-hydroxy-N-[[...)
Affinity DataIC50: 100nMAssay Description:The inhibitory activity of compounds was evaluated in vitro using TR-FRET assay with white 384-well low volume microplate (PerkinElmer ProxiPlate Plu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2024
Entry Details
Go to US Patent