BDBM643130 US20240002339, Example 67

SMILES OC(=O)c1cc(SC(F)(F)F)ccc1NCCc1c[nH]c2cc(ccc12)C#N

InChI Key InChIKey=DYUJZFWTXBXMAL-UHFFFAOYSA-N

Data  1 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 643130   

TargetCyclin-dependent kinase 2(Human)
University of Minnesota

US Patent
LigandPNGBDBM643130(US20240002339, Example 67)
Affinity DataIC50: 100nMAssay Description:CDK2 was thawed at room temperature and buffer exchanged using Zeba spin desalting columns. The final ITC buffer was 1×PBS, 10 mM MgCl2, and 5% glyce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2024
Entry Details
Go to US Patent

TargetCyclin-dependent kinase 2(Human)
University of Minnesota

US Patent
LigandPNGBDBM643130(US20240002339, Example 67)
Affinity DataKd:  7.30nMAssay Description:Compounds in DMSO (1% final) were added to 384-well black clear bottom plates (Greiner 781091) in 8-point dose response in duplicate using the Echo 5...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2024
Entry Details
Go to US Patent