BDBM642776 4-(difluoromethyl)-N-(1-((difluoromethyl)sulfonyl)piperidin-4-yl)-1- isopropyl-1H-[1,2,3]triazolo[4,5-h]quinazolin-8-amine::US20230416271, Compound II.30

SMILES CC(C)n1nnc2c(cc3cnc(NC4CCN(CC4)S(=O)(=O)C(F)F)nc3c12)C(F)F

InChI Key InChIKey=VISMKLIGDLCELE-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 642776   

TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
Chengdu Cynogen Bio-Pharmaceutical Technology

US Patent
LigandPNGBDBM642776(4-(difluoromethyl)-N-(1-((difluoromethyl)sulfonyl)...)
Affinity DataIC50: 0.300nMAssay Description:Assay of Kinase Activity The inhibitory effect of compounds against the kinase CDK4/cyclin D3 was detected by Caliper Mobility Shift Assay method. Th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2024
Entry Details
Go to US Patent

TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D3(Human)
Chengdu Cynogen Bio-Pharmaceutical Technology

US Patent
LigandPNGBDBM642776(4-(difluoromethyl)-N-(1-((difluoromethyl)sulfonyl)...)
Affinity DataIC50: 3nMAssay Description:Assay of Kinase Activity The inhibitory effect of compounds against the kinase CDK4/cyclin D3 was detected by Caliper Mobility Shift Assay method. Th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2024
Entry Details
Go to US Patent

TargetCyclin-dependent kinase 6/G1/S-specific cyclin-D3(Human)
Chengdu Cynogen Bio-Pharmaceutical Technology

US Patent
LigandPNGBDBM642776(4-(difluoromethyl)-N-(1-((difluoromethyl)sulfonyl)...)
Affinity DataIC50: 6nMAssay Description:Assay of Kinase Activity The inhibitory effect of compounds against the kinase CDK4/cyclin D3 was detected by Caliper Mobility Shift Assay method. Th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2024
Entry Details
Go to US Patent