BDBM642342 2-{5-[(3-ethoxypyridin-2-yl)oxy]pyridin-3- yl}-N-[(3R)-piperidin-3-yl]pyrimidine-5- carboxamide::US20230405002, Example 22

SMILES CCOc1cccnc1Oc1cncc(c1)-c1ncc(cn1)C(=O)N[C@@H]1CCCNC1

InChI Key InChIKey=FAVXKPAYKQWSMQ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 642342   

TargetDiacylglycerol O-acyltransferase 2(Human)
Pfizer

US Patent
LigandPNGBDBM642342(2-{5-[(3-ethoxypyridin-2-yl)oxy]pyridin-3- yl}-N-[...)
Affinity DataIC50: 2.10E+4nMAssay Description:For determination of IC50 values, the reactions were carried out in 384-well white polypropylene plates (Nunc) in a total volume of 20 μL. To 1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2024
Entry Details
Go to US Patent

TargetDiacylglycerol O-acyltransferase 2(Human)
Pfizer

US Patent
LigandPNGBDBM642342(2-{5-[(3-ethoxypyridin-2-yl)oxy]pyridin-3- yl}-N-[...)
Affinity DataIC50: 2.10E+4nMAssay Description:Inhibition of human DGAT2 using 14C decanoyl-CoA as a substrate pre incubated for 2 hrs followed by substrate addition measured after 40 mins by Tril...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed