BDBM640382 Preparation of 3-((4-amino-7-((1r,4r)-4-hydroxycyclohexyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)ethynyl)-4-methyl-N-(4-methyl-3-(trifluoromethyl)phenyl)benzamide ::US11840535, Example 24

SMILES Cc1ccc(cc1C#Cc1cn([C@H]2CC[C@H](O)CC2)c2ncnc(N)c12)C(=O)Nc1ccc(C)c(c1)C(F)(F)F

InChI Key InChIKey=PZVWYWLYIMTXHB-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 640382   

TargetTyrosine-protein kinase ABL1(Human)
Shenzhen Targetrx

US Patent
LigandPNGBDBM640382(Preparation of 3-((4-amino-7-((1r,4r)-4-hydroxycyc...)
Affinity DataIC50: 5nMAssay Description:Specific Assay Method:Compound formulation: The test compounds were dissolved in DMSO to prepare a 20 mM stock solution. Before use, the compounds we...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTyrosine-protein kinase ABL1 [T315I](Human)
Shenzhen Targetrx

US Patent
LigandPNGBDBM640382(Preparation of 3-((4-amino-7-((1r,4r)-4-hydroxycyc...)
Affinity DataIC50: 27.5nMAssay Description:Specific Assay Method:Compound formulation: The test compounds were dissolved in DMSO to prepare a 20 mM stock solution. Before use, the compounds we...More data for this Ligand-Target Pair
In DepthDetails
US Patent