BDBM637565 (3-amino-6-cyclopropyl-1H- pyrazolo[3,4-b]pyridin-1-yl)(2- (trifluoromethyl)pyridin-3- yl)methanone::US20230382911, Example 77

SMILES Nc1nn(C(=O)c2cccnc2C(F)(F)F)c2nc(ccc12)C1CC1

InChI Key InChIKey=OBBDEDAOHFFTMI-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 637565   

TargetS-adenosylmethionine synthase isoform type-2(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM637565((3-amino-6-cyclopropyl-1H- pyrazolo[3,4-b]pyridin-...)
Affinity DataIC50: 31nMAssay Description:Recombinant human Mat2a (12.5 nM) and serial diluted compounds in DMSO (range of concentrations from 10 μM to 508 μM) or controls (DMSO) ar...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2024
Entry Details
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