BDBM6374 8-Cyclopentyl-2-{4-[4-(2-hydroxy-ethyl)-piperazin-1-yl]-phenylamino}-5-methyl-8H-pyrido[2,3-d]pyrimidin-7-one::8-cyclopentyl-2-({4-[4-(2-hydroxyethyl)piperazin-1-yl]phenyl}amino)-5-methyl-7H,8H-pyrido[2,3-d]pyrimidin-7-one::pyrido[2,3-d]pyrimidin-7-one 21

SMILES Cc1cc(=O)n(C2CCCC2)c2nc(Nc3ccc(cc3)N3CCN(CCO)CC3)ncc12

InChI Key InChIKey=ARWTTWBSMVHBPU-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 6374   

LigandPNGBDBM6374(8-Cyclopentyl-2-{4-[4-(2-hydroxy-ethyl)-piperazin-...)
Affinity DataIC50: 35nMAssay Description:The enzyme was assayed with substrate GST- retinoblastoma in the presence of 25 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2005
Entry Details Article
PubMed
LigandPNGBDBM6374(8-Cyclopentyl-2-{4-[4-(2-hydroxy-ethyl)-piperazin-...)
Affinity DataIC50: 5.00E+3nMAssay Description:The enzyme was assayed with substrate GST- retinoblastoma in the presence of 25 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2005
Entry Details Article
PubMed
LigandPNGBDBM6374(8-Cyclopentyl-2-{4-[4-(2-hydroxy-ethyl)-piperazin-...)
Affinity DataIC50: 5.00E+3nMAssay Description:The enzyme was assayed with substrate GST- retinoblastoma in the presence of 25 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2005
Entry Details Article
PubMed
LigandPNGBDBM6374(8-Cyclopentyl-2-{4-[4-(2-hydroxy-ethyl)-piperazin-...)
Affinity DataIC50: 5.00E+3nMAssay Description:The enzyme was assayed with substrate GST- retinoblastoma in the presence of 25 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2005
Entry Details Article
PubMed