BDBM636718 US11826430, Compound 1.2a

SMILES Cn1ncnc1[C@@H]1[C@H](Nc2cc(F)cc3c2c1n[nH]c3=O)c1ccc(cc1)N1C(=S)N(C(=O)C1(C)C)c1ccc(C#N)c(c1)C(F)(F)F

InChI Key InChIKey=NHTFNTYBBURGHS-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 636718   

TargetPoly [ADP-ribose] polymerase 1(Human)
Nuvation Bio

US Patent
LigandPNGBDBM636718(US11826430, Compound 1.2a)
Affinity DataIC50: 1nMAssay Description:i. PARP1 assay: Human recombinant PARP1 at a final concentration of 2.5 nM was combined with histone H4 (20 μM) and test articles at various con...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetPoly [ADP-ribose] polymerase 2(Human)
Nuvation Bio

US Patent
LigandPNGBDBM636718(US11826430, Compound 1.2a)
Affinity DataIC50: 0.300nMAssay Description:i. PARP1 assay: Human recombinant PARP1 at a final concentration of 2.5 nM was combined with histone H4 (20 μM) and test articles at various con...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetAndrogen receptor(Human)
Nuvation Bio

US Patent
LigandPNGBDBM636718(US11826430, Compound 1.2a)
Affinity DataIC50: 3.75E+3nMAssay Description:AR in LNCaP cytosol was used for determining the binding affinity of test articles and the reference compound progesterone (Sigma, Cat: E2785, St. Lo...More data for this Ligand-Target Pair
In DepthDetails
US Patent