BDBM636143 (1R,2S)-2-{3-[2-ethoxy-4-(methanesulfonyl)anilino]-1H-indazol-6-yl}-5'-methoxyspiro[cyclopropane-1,3'-indol]-2'(1'H)-one::US20230365537, Example 272

SMILES CCOc1cc(ccc1Nc1n[nH]c2cc(ccc12)[C@@H]1C[C@@]11C(=O)Nc2ccc(OC)cc12)S(C)(=O)=O

InChI Key InChIKey=MBNSFOGJHWUIOY-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 636143   

TargetSerine/threonine-protein kinase PLK4(Human)
Oric Pharmaceuticals

US Patent
LigandPNGBDBM636143(US20230365537, Example 272 | (1R,2S)-2-{3-[2-ethox...)
Affinity DataIC50: 0.833nMAssay Description:Activity of human recombinant PLK4 (ThermoFisher, cat #PV6396) was measured by quantification of adenosine diphosphate (ADP) using the ADP-Glo Kinase...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2024
Entry Details
Go to US Patent

TargetAurora kinase A(Human)
Oric Pharmaceuticals

US Patent
LigandPNGBDBM636143(US20230365537, Example 272 | (1R,2S)-2-{3-[2-ethox...)
Affinity DataIC50: 2.73E+3nMAssay Description:Activity of human recombinant Aurora A (ThermoFisher, cat #PR5935A) was measured by quantification of adenosine diphosphate (ADP) using the ADP-Glo K...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2024
Entry Details
Go to US Patent

TargetAurora kinase B(Human)
Oric Pharmaceuticals

US Patent
LigandPNGBDBM636143(US20230365537, Example 272 | (1R,2S)-2-{3-[2-ethox...)
Affinity DataIC50: 374nMAssay Description:Activity of human recombinant Aurora B (ThermoFisher, cat #PR9210B) was measured by quantification of adenosine diphosphate (ADP) using the ADP-Glo K...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2024
Entry Details
Go to US Patent