BDBM6347 2-Aminoquinazoline 26::8-cyclopentyl-2-{[4-(piperazin-1-yl)phenyl]amino}quinazolin-7-ol

SMILES Oc1ccc2cnc(Nc3ccc(cc3)N3CCNCC3)nc2c1C1CCCC1

InChI Key InChIKey=TWOLZYGLMTWBFU-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 6347   

LigandPNGBDBM6347(8-cyclopentyl-2-{[4-(piperazin-1-yl)phenyl]amino}q...)
Affinity DataIC50: 30nMAssay Description:The enzyme was assayed with substrate GST- retinoblastoma in the presence of 12 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2005
Entry Details Article
PubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
Naeja Pharmaceutical

LigandPNGBDBM6347(8-cyclopentyl-2-{[4-(piperazin-1-yl)phenyl]amino}q...)
Affinity DataIC50: 82nMAssay Description:The enzyme was assayed with substrate GST- retinoblastoma in the presence of 12 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
Naeja Pharmaceutical

LigandPNGBDBM6347(8-cyclopentyl-2-{[4-(piperazin-1-yl)phenyl]amino}q...)
Affinity DataIC50: 320nMAssay Description:The enzyme was assayed with substrate GST- retinoblastoma in the presence of 12 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2005
Entry Details Article
PubMed
LigandPNGBDBM6347(8-cyclopentyl-2-{[4-(piperazin-1-yl)phenyl]amino}q...)
Affinity DataIC50: 1nMAssay Description:The enzyme was assayed with substrate GST- retinoblastoma in the presence of 12 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
Naeja Pharmaceutical

LigandPNGBDBM6347(8-cyclopentyl-2-{[4-(piperazin-1-yl)phenyl]amino}q...)
Affinity DataIC50: 324nMAssay Description:Inhibition of CDK2/Cyclin E (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2017
Entry Details Article
PubMed