BDBM6334 2-Aminoquinazoline 12::N-[3-fluoro-4-(piperazin-1-yl)phenyl]-7-methoxy-8-(propan-2-yl)quinazolin-2-amine

SMILES COc1ccc2cnc(Nc3ccc(N4CCNCC4)c(F)c3)nc2c1C(C)C

InChI Key InChIKey=YTAJPEIDLGHFLU-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 6334   

LigandPNGBDBM6334(N-[3-fluoro-4-(piperazin-1-yl)phenyl]-7-methoxy-8-...)
Affinity DataIC50: 743nMpH: 7.4 T: 2°CAssay Description:The enzyme was assayed with substrate GST- retinoblastoma in the presence of 12 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2005
Entry Details Article
PubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
Naeja Pharmaceutical

LigandPNGBDBM6334(N-[3-fluoro-4-(piperazin-1-yl)phenyl]-7-methoxy-8-...)
Affinity DataIC50: 141nMAssay Description:The enzyme was assayed with substrate GST- retinoblastoma in the presence of 12 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
Naeja Pharmaceutical

LigandPNGBDBM6334(N-[3-fluoro-4-(piperazin-1-yl)phenyl]-7-methoxy-8-...)
Affinity DataIC50: 655nMAssay Description:The enzyme was assayed with substrate GST- retinoblastoma in the presence of 12 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2005
Entry Details Article
PubMed
LigandPNGBDBM6334(N-[3-fluoro-4-(piperazin-1-yl)phenyl]-7-methoxy-8-...)
In Depth
Date in BDB:
11/2/2005
Entry Details Article
PubMed