BDBM631083 N-(2,6-dioxo-3-piperidyl)benzamide::US11802131, Example 10

SMILES O=C(NC1CCC(=O)NC1=O)c1ccccc1

InChI Key InChIKey=QDCDITVKCKBZTO-UHFFFAOYSA-N

Data  1 KI  1 IC50  1 Kd  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 631083   

TargetDNA damage-binding protein 1/Protein cereblon(Human)
C4 Therapeutics

US Patent
LigandPNGBDBM631083(US11802131, Example 10 | N-(2,6-dioxo-3-piperidyl)...)
Affinity DataKd:  20nMAssay Description:Determination of the affinities of compounds to protein containing one or more tryptophan is measurable by monitoring the fluorescence emission in di...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetProtein cereblon(Human)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM631083(US11802131, Example 10 | N-(2,6-dioxo-3-piperidyl)...)
Affinity DataIC50: 1.27E+5nMAssay Description:Binding affinity to human CRBN TBD using BODIPY-uracil as substrate by MST assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetZinc finger protein Aiolos(Homo sapiens)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM631083(US11802131, Example 10 | N-(2,6-dioxo-3-piperidyl)...)
Affinity DataEC50: >1.00E+4nMAssay Description:Induction of ePL tagged Aiolos degradation in human DF15 cells incubated for 4 hrs by luminescence based assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetProtein cereblon(Human)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM631083(US11802131, Example 10 | N-(2,6-dioxo-3-piperidyl)...)
Affinity DataKi:  6.30E+4nMAssay Description:Binding affinity to human CRBN TBD assessed as inhibition constant using BODIPY-uracil as substrate by MST assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed