BDBM630933 (4S)-N-{((R or S)-3- chloro-4- fluorophenyl)[5-fluoro- 6-(2,2,2-trifluoro- ethoxy)pyridin-2- yl]methyl}-2- oxoimidazolidine-4- carboxamide::US11802122, Example 11A::US11802122, Example 11B

SMILES Fc1ccc(cc1Cl)C(NC(=O)[C@@H]1CNC(=O)N1)c1ccc(F)c(OCC(F)(F)F)n1

InChI Key InChIKey=IQKIYXKZUQZQIB-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 630933   

TargetSodium channel protein type 8 subunit alpha(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM630933(US11802122, Example 11A | US11802122, Example 11B ...)
Affinity DataIC50: 50nMAssay Description:The following buffers were used for the Qube recordings: External buffer for NaV1.8 Qube recording: 150 NaCl, 2 CaCl2, 5 KCl, 1 Mg Cl2, 10 HEPES, 12 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2023
Entry Details
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TargetSodium channel protein type 8 subunit alpha(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM630933(US11802122, Example 11A | US11802122, Example 11B ...)
Affinity DataIC50: 3.90nMAssay Description:The following buffers were used for the Qube recordings: External buffer for NaV1.8 Qube recording: 150 NaCl, 2 CaCl2, 5 KCl, 1 Mg Cl2, 10 HEPES, 12 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2023
Entry Details
Go to US Patent