BDBM629344 US20230339981, Example 28::US20240199644, Compound 7
SMILES Oc1cc(-c2nc3OC[C@@H]4[C@@H]5CC[C@H](CN4c4nc(OCC6(CN7CCOCC7)CC6)nc(c2F)c34)N5)c2c(C#C)c(F)ccc2c1
InChI Key InChIKey=JQADGZCFGZVFDH-UHFFFAOYSA-N
Data 2 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 2 hits for monomerid = 629344
Affinity DataIC50: 0.600nMAssay Description:Compounds were tested for binding to GDP-loaded KRAS G12D in a 384-well assay format using a TR-FRET probe displacement assay in buffer consisting of...More data for this Ligand-Target Pair
TargetRAF proto-oncogene serine/threonine-protein kinase [50-132]/GTPase KRas [1-169,G12D](Human)
Jacobio Pharmaceuticals
US Patent
Jacobio Pharmaceuticals
US Patent
Affinity DataIC50: 0.659nMAssay Description:GppNp-loaded HIS-KRAS(G12D, aa 1-169) was pre-incubated with a compound in the presence of 200 uM GTP in a 384-well plate (Greiner) for 15 min, then ...More data for this Ligand-Target Pair