BDBM626343 2-[[[4-carbamoyl-7-(4- isopropylphenyl)-2,3- dihydrobenzofuran-5- yl]amino]methyl]prop-2-enoic acid::US11787775, Compound 34

SMILES CC(C)c1ccc(cc1)-c1cc(NCC(=C)C(O)=O)c(C(N)=O)c2CCOc12

InChI Key InChIKey=FPCSPUQDYKULPK-UHFFFAOYSA-N

Data  4 IC50  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 626343   

TargetTranscriptional enhancer factor TEF-1(Human)
Genentech

US Patent
LigandPNGBDBM626343(2-[[[4-carbamoyl-7-(4- isopropylphenyl)-2,3- dih...)
Affinity DataIC50: 1.80E+3nMAssay Description:Table 2-3: His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid p...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTranscriptional enhancer factor TEF-4(Human)
Genentech

US Patent
LigandPNGBDBM626343(2-[[[4-carbamoyl-7-(4- isopropylphenyl)-2,3- dih...)
Affinity DataIC50: 970nMAssay Description:Table 2-3: His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid p...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTranscriptional enhancer factor TEF-5(Human)
Genentech

US Patent
LigandPNGBDBM626343(2-[[[4-carbamoyl-7-(4- isopropylphenyl)-2,3- dih...)
Affinity DataIC50: 5.00E+4nMAssay Description:Table 2-3: His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid p...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTranscriptional enhancer factor TEF-3(Human)
Genentech

US Patent
LigandPNGBDBM626343(2-[[[4-carbamoyl-7-(4- isopropylphenyl)-2,3- dih...)
Affinity DataIC50: 330nMAssay Description:Table 2-3: His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid p...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM626343(2-[[[4-carbamoyl-7-(4- isopropylphenyl)-2,3- dih...)
Affinity DataEC50:  1.00E+3nMAssay Description:Table 4-5: Purified His-tagged TEAD protein (YAP Binding Domain, amino acids 217-447) is pre-incubated with Europium labelled anti-His antibody trace...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM626343(2-[[[4-carbamoyl-7-(4- isopropylphenyl)-2,3- dih...)
Affinity DataEC50:  580nMAssay Description:Table 4-5: Purified His-tagged TEAD protein (YAP Binding Domain, amino acids 217-447) is pre-incubated with Europium labelled anti-His antibody trace...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM626343(2-[[[4-carbamoyl-7-(4- isopropylphenyl)-2,3- dih...)
Affinity DataEC50: >5.00E+4nMAssay Description:Table 4-5: Purified His-tagged TEAD protein (YAP Binding Domain, amino acids 217-447) is pre-incubated with Europium labelled anti-His antibody trace...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM626343(2-[[[4-carbamoyl-7-(4- isopropylphenyl)-2,3- dih...)
Affinity DataEC50:  700nMAssay Description:Table 4-5: Purified His-tagged TEAD protein (YAP Binding Domain, amino acids 217-447) is pre-incubated with Europium labelled anti-His antibody trace...More data for this Ligand-Target Pair
In DepthDetails
US Patent