BDBM626339 2-[[[6-methoxy-5-[(E)-2-[trans-4- (trifluoromethyl)cyclohexyl]vinyl]- 3-pyridyl]amino]methyl]prop-2- enoic acid::US11787775, Compound 25

SMILES COc1ncc(NCC(=C)C(O)=O)cc1\C=C\[C@H]1CC[C@@H](CC1)C(F)(F)F

InChI Key InChIKey=SVVXZVOOYUATGC-UHFFFAOYSA-N

Data  4 IC50  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 626339   

TargetTranscriptional enhancer factor TEF-1(Human)
Genentech

US Patent
LigandPNGBDBM626339(2-[[[6-methoxy-5-[(E)-2-[trans-4- (trifluoromethy...)
Affinity DataIC50: 580nMAssay Description:Table 2-3: His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2023
Entry Details
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TargetTranscriptional enhancer factor TEF-4(Human)
Genentech

US Patent
LigandPNGBDBM626339(2-[[[6-methoxy-5-[(E)-2-[trans-4- (trifluoromethy...)
Affinity DataIC50: 270nMAssay Description:Table 2-3: His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2023
Entry Details
Go to US Patent

TargetTranscriptional enhancer factor TEF-5(Human)
Genentech

US Patent
LigandPNGBDBM626339(2-[[[6-methoxy-5-[(E)-2-[trans-4- (trifluoromethy...)
Affinity DataIC50: 1.25E+3nMAssay Description:Table 2-3: His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2023
Entry Details
Go to US Patent

TargetTranscriptional enhancer factor TEF-3(Human)
Genentech

US Patent
LigandPNGBDBM626339(2-[[[6-methoxy-5-[(E)-2-[trans-4- (trifluoromethy...)
Affinity DataIC50: 140nMAssay Description:Table 2-3: His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2023
Entry Details
Go to US Patent

LigandPNGBDBM626339(2-[[[6-methoxy-5-[(E)-2-[trans-4- (trifluoromethy...)
Affinity DataEC50: >5.00E+4nMAssay Description:Table 4-5: Purified His-tagged TEAD protein (YAP Binding Domain, amino acids 217-447) is pre-incubated with Europium labelled anti-His antibody trace...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2023
Entry Details
Go to US Patent

LigandPNGBDBM626339(2-[[[6-methoxy-5-[(E)-2-[trans-4- (trifluoromethy...)
Affinity DataEC50: >5.00E+4nMAssay Description:Table 4-5: Purified His-tagged TEAD protein (YAP Binding Domain, amino acids 217-447) is pre-incubated with Europium labelled anti-His antibody trace...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2023
Entry Details
Go to US Patent

LigandPNGBDBM626339(2-[[[6-methoxy-5-[(E)-2-[trans-4- (trifluoromethy...)
Affinity DataEC50: >5.00E+4nMAssay Description:Table 4-5: Purified His-tagged TEAD protein (YAP Binding Domain, amino acids 217-447) is pre-incubated with Europium labelled anti-His antibody trace...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2023
Entry Details
Go to US Patent

LigandPNGBDBM626339(2-[[[6-methoxy-5-[(E)-2-[trans-4- (trifluoromethy...)
Affinity DataEC50: >5.00E+4nMAssay Description:Table 4-5: Purified His-tagged TEAD protein (YAP Binding Domain, amino acids 217-447) is pre-incubated with Europium labelled anti-His antibody trace...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2023
Entry Details
Go to US Patent