BDBM621968 (S)-N-((R or S)-(4- chlorophenyl)(7,7- difluorobicyclo[4.2.0] octa-1(6),2,4-trien-3- yl)methyl)-2- oxoimidazolidine-4- carboxamide::US11802122, Example 90::US20230312528, Example 90

SMILES FC1(F)Cc2cc(ccc12)C(NC(=O)[C@@H]1CNC(=O)N1)c1ccc(Cl)cc1

InChI Key InChIKey=QIUZPJRLNIDZJM-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 621968   

TargetSodium channel protein type 8 subunit alpha(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM621968(US20230312528, Example 90 | US11802122, Example 90...)
Affinity DataIC50: 3.80nMAssay Description:The following buffers were used for the Qube recordings: External buffer for NaV1.8 Qube recording: 150 NaCl, 2 CaCl2, 5 KCl, 1 Mg Cl2, 10 HEPES, 12 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2023
Entry Details
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TargetSodium channel protein type 8 subunit alpha(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM621968(US20230312528, Example 90 | US11802122, Example 90...)
Affinity DataIC50: 3.80nMAssay Description:Compounds were tested on human NaV1.8 and NaV1.5 channels stably expressed in human embryo kidney (HEK) 293 cells. Sodium current measurements on Qub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2023
Entry Details
Go to US Patent